Biography
Biography: Jinsong Hao
Abstract
Statement of the Problem: Chronic wound healing has been a clinical challenge. Th ere is an urgent need to develop novel wound healing therapeutics. Cardiotonic steroids (CTS) have been used for the treatment of cardiac diseases and their mechanisms of action are associated with Na/K-ATPase. It was reported that the binding of CTS with the Na/K-ATPase resulted in increased collagen synthesis by dermal fi broblasts. Th e objective of this study was to determine the wound healing eff ect of a model cardiotonic steroid in a wound model. Methodology: Full-thickness wounds were created in rats by a biopsy punch. Th e vehicle alone or a testing CTS solution was applied to the wounds. Findings: Increased collagen synthesis by dermal fi broblasts aft er exposure to the CTS was observed. Th e wound closure rate was signifi cantly increased following the treatment with the CTS. Conclusion & Signifi cance: Th e CTS primarily elicited a wound healing eff ect in the proliferation phase and might be a potential wound healing therapeutics.