Regina Folster-Holst
University Medical Centre Schleswig-Holstein
Title: Epidermal barrier structure and function in atopic dermatitis and ichthyosis
Biography
Biography: Regina Folster-Holst
Abstract
The clinical phenotype of atopic dermatitis (AD) results from complex interactions between genetic and environmental factors, which influence the epidermal structure and function, as well as the immune system. In addition, neurogenic disturbances and loss of the diversity of microbiome (intestinal and cutaneous) are causes of exacerbation. Epidermal barrier defects seem to be a hallmark of pathogenesis of AD. The quality of the skin barrier can be assessed by using a new semiquantitative method to measure intercellular lipid lamellae. This procedure was used to evaluate the influence of emollients and also the topical application of drugs like corticosteroid and calcineurin inhibitors