Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 2nd International Conference on Advances in Skin, Wound Care and Tissue Science Frankfurt, Germany.

Day 2 :

Keynote Forum

Edgar Serfling

University of Würzburg, Germany

Keynote: NFATC1 enhances imiquimod-induced skin inflammation by inhibiting IL-10 expression in B lymphocytes

Time : 09:30-10:15

OMICS International Wound Congress 2017 International Conference Keynote Speaker Edgar Serfling photo
Biography:

Edgar Serfling has been graduated from the University of Halle/Wittenberg as PhD and of University of Wuerzburg (Habilitation), with the specialties in Biochemistry and Molecular Pathology. Later on, he obtained his post-graduation from University of Wuerzburg and then started working at the Institutes of Virology and Immunobiology, and of Pathology where he has continued his research. Presently he has been working at the Institute of Pathology, Wuerzburg, Germany.

Abstract:

Psoriasis is a chronic inflammatory skin disease that affects 2-3% of population in Western countries. Since B cells are hardly detected in psoriatic skin, until recently their role in psoriasis remained un-regarded. We show here that the repetitive epicutaneous application of Aldara®, a cream containing the toll-like reptor (TLR) 7-agonist imiquimod (IMQ), to mice induces skin inflammation that exhibits many aspects of early stages of human psoriasis. Mice depleted of B cells or bearing IL-10-deficient B cells show an even more fulminant inflammation upon IMQ exposure indicating that IL-10 synthesized in B cells controls skin inflammation. In contrast, ablation of NFATc1 in B cells results in depressed IMQ-induced skin inflammation. Aldara® cream application to the skin leads to the differentiation of splenic B cells to plasmablasts and IL-10-producing B cells. In vitro, IMQ induces the proliferation and IL-10 expression of splenic B cells. The induction of IL-10 RNA by IMQ can be blocked by a-IgM-mediated B cell receptor signals that, on the other hand, induce NFATc1. By binding to HDAC1, NFATc1 suppresses IL-10 expression, which, otherwise, dampens the production of inflammatory cytokines by T cells, including TNFa and IL-17. These data indicate a close link between NFATc1 and IL-10 expression in B cells during IMQ-mediated skin inflammation and suggest that the suppression of NFATc1 activity might be of benefit to treat human psoriasis and, possibly, other autoimmune diseases as well.

 

Keynote Forum

Pedro Morouço

Polytechnic Institute of Leiria, Portugal

Keynote: Biofabrication for cartilage regeneration: Engineering biomaterials and printing processes

Time : 10:15-11:00

OMICS International Wound Congress 2017 International Conference Keynote Speaker Pedro Morouço photo
Biography:

Pedro Morouço is a very enthusiastic and provoking early-career researcher. Currently he is the Head of R&D Biofabrication Group at the Centre for Rapid and Sustainable Product Development – Polytechnic Institute of Leiria, Portugal. He is the Principal Investigator of “2bio4cartilage – Integrated intervention program for prevention and treatment of cartilage lesions”, and his research activity focuses, mostly, on products and processes engineering, aiming to bringing the gap between the lab and in vivo applications. In the last years, he has been invited to collaborate in several national and international projects, providing a significant income for the Biofabrication Group (currently has 8 grant-holders). Despite his young age, he has co-edited books, authored, co-authored more than 150 scientific works, member of the scientific committees in various conferences, member of the advisory board on TERM for Cambridge Scholars Publishing, editorial member in various journals, and keynote speaker for Stem Cell and Regenerative Medicine 2016(Manchester, UK) and Tissue Engineering and Regenerative Medicine 2016 (Berlin) & 2017 (Barcelona).

Abstract:

Pedro Morouço is a very enthusiastic and provoking early-career researcher. Currently he is the Head of R&D Biofabrication Group at the Centre for Rapid and Sustainable Product Development – Polytechnic Institute of Leiria, Portugal. He is the Principal Investigator of “2bio4cartilage – Integrated intervention program for prevention and treatment of cartilage lesions”, and his research activity focuses, mostly, on products and processes engineering, aiming to bringing the gap between the lab and in vivo applications. In the last years, he has been invited to collaborate in several national and international projects, providing a significant income for the Biofabrication Group (currently has 8 grant-holders). Despite his young age, he has co-edited books, authored, co-authored more than 150 scientific works, member of the scientific committees in various conferences, member of the advisory board on TERM for Cambridge Scholars Publishing, editorial member in various journals, and keynote speaker for Stem Cell and Regenerative Medicine 2016(Manchester, UK) and Tissue Engineering and Regenerative Medicine 2016 (Berlin) & 2017 (Barcelona).